101 - Document - Document And Entity Information link:presentationLink link:definitionLink link:calculationLink 102 - Statement - CONSOLIDATED BALANCE SHEETS link:presentationLink link:definitionLink link:calculationLink 103 - Statement - CONSOLIDATED BALANCE SHEETS (Parenthetical) link:presentationLink link:definitionLink link:calculationLink 104 - Statement - CONSOLIDATED STATEMENTS OF OPERATIONS link:presentationLink link:definitionLink link:calculationLink 105 - Statement - CONSOLIDATED STATEMENT OF STOCKHOLDERS' EQUITY (DEFICIT) link:presentationLink link:definitionLink link:calculationLink 106 - Statement - CONSOLIDATED STATEMENTS OF CASH FLOWS link:presentationLink link:definitionLink link:calculationLink 107 - Disclosure - NATURE OF OPERATIONS link:presentationLink link:definitionLink link:calculationLink 108 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES link:presentationLink link:definitionLink link:calculationLink 109 - Disclosure - NET LOSS PER SHARE APPLICABLE TO COMMON SHAREHOLDER link:presentationLink link:definitionLink link:calculationLink 110 - Disclosure - ACCOUNTS PAYABLE AND ACCRUED LIABILITIES link:presentationLink link:definitionLink link:calculationLink 111 - Disclosure - RESEARCH AGREEMENT OBLIGATIONS link:presentationLink link:definitionLink link:calculationLink 112 - Disclosure - WARRANT LIABILITY link:presentationLink link:definitionLink link:calculationLink 113 - Disclosure - FAIR VALUE MEASUREMENTS link:presentationLink link:definitionLink link:calculationLink 114 - Disclosure - STOCKHOLDERS’ EQUITY link:presentationLink link:definitionLink link:calculationLink 115 - Disclosure - WARRANTS link:presentationLink link:definitionLink link:calculationLink 116 - Disclosure - STOCK OPTION PLANS link:presentationLink link:definitionLink link:calculationLink 117 - Disclosure - GRANT INCOME link:presentationLink link:definitionLink link:calculationLink 118 - Disclosure - CONTINGENCIES AND COMMITMENTS link:presentationLink link:definitionLink link:calculationLink 119 - Disclosure - LEGAL PROCEEDINGS link:presentationLink link:definitionLink link:calculationLink 120 - Disclosure - INCOME TAXES link:presentationLink link:definitionLink link:calculationLink 121 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Policies) link:presentationLink link:definitionLink link:calculationLink 122 - Disclosure - NET LOSS PER SHARE APPLICABLE TO COMMON SHAREHOLDER (Tables) link:presentationLink link:definitionLink link:calculationLink 123 - Disclosure - ACCOUNTS PAYABLE AND ACCRUED LIABILITIES (Tables) link:presentationLink link:definitionLink link:calculationLink 124 - Disclosure - WARRANT LIABILITY (Tables) link:presentationLink link:definitionLink link:calculationLink 125 - Disclosure - FAIR VALUE MEASUREMENTS (Tables) link:presentationLink link:definitionLink link:calculationLink 126 - Disclosure - STOCKHOLDERS’ EQUITY (Tables) link:presentationLink link:definitionLink link:calculationLink 127 - Disclosure - WARRANTS (Tables) link:presentationLink link:definitionLink link:calculationLink 128 - Disclosure - STOCK OPTION PLANS (Tables) link:presentationLink link:definitionLink link:calculationLink 129 - Disclosure - CONTINGENCIES AND COMMITMENTS (Tables) link:presentationLink link:definitionLink link:calculationLink 130 - Disclosure - INCOME TAXES (Tables) link:presentationLink link:definitionLink link:calculationLink 131 - Disclosure - NATURE OF OPERATIONS - Additional Information (Detail) link:presentationLink link:definitionLink link:calculationLink 132 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES - Additional Information (Detail) link:presentationLink link:definitionLink link:calculationLink 133 - Disclosure - NET LOSS PER SHARE APPLICABLE TO COMMON SHAREHOLDER - Computation of income (loss) per share (Detail) link:presentationLink link:definitionLink link:calculationLink 134 - Disclosure - NET LOSS PER SHARE APPLICABLE TO COMMON SHAREHOLDER - Potentially Dilutive Securities (Detail) link:presentationLink link:definitionLink link:calculationLink 135 - Disclosure - ACCOUNTS PAYABLE AND ACCRUED LIABILITIES -Accounts payable and accrued liabilities (Detail) link:presentationLink link:definitionLink link:calculationLink 136 - Disclosure - RESEARCH AGREEMENT OBLIGATIONS - Additional Information (Detail) link:presentationLink link:definitionLink link:calculationLink 137 - Disclosure - WARRANT LIABILITY - Conversion Option - Valuation Methodology (Detail) link:presentationLink link:definitionLink link:calculationLink 138 - Disclosure - WARRANT LIABILITY - Conversion Option - Schedule of Changes in Level 3 Liabilities Reflected in Accrued Expenses Measured at Fair Value (Detail) link:presentationLink link:definitionLink link:calculationLink 139 - Disclosure - FAIR VALUE MEASUREMENTS - Conversion Option - Financial Assets and Liabilities Measured at Fair Value on a Recurring Basis (Detail) link:presentationLink link:definitionLink link:calculationLink 140 - Disclosure - FAIR VALUE MEASUREMENTS - Additional Information (Detail) link:presentationLink link:definitionLink link:calculationLink 141 - Disclosure - STOCKHOLDERS' EQUITY - Summary of number of price-reduced and price-retained warrants (Detail) link:presentationLink link:definitionLink link:calculationLink 142 - Disclosure - STOCKHOLDERS' EQUITY - Conversion Option - Valuation Methodology (Detail) link:presentationLink link:definitionLink link:calculationLink 143 - Disclosure - STOCKHOLDERS’ EQUITY - Additional Information (Detail) link:presentationLink link:definitionLink link:calculationLink 144 - Disclosure - WARRANTS - Share Purchase Warrants (Detail) link:presentationLink link:definitionLink link:calculationLink 145 - Disclosure - WARRANTS-Amendment Agreement and private placement (Detail) link:presentationLink link:definitionLink link:calculationLink 146 - Disclosure - WARRANTS - Summary of number of price-reduced and price-retained warrants (Detail) link:presentationLink link:definitionLink link:calculationLink 147 - Disclosure - WARRANTS- Additional Information (Detail) link:presentationLink link:definitionLink link:calculationLink 148 - Disclosure - STOCK OPTION PLANS - Stock Option Activity (Detail) link:presentationLink link:definitionLink link:calculationLink 149 - Disclosure - STOCK OPTION PLANS - Weighted Average Assumptions (Detail) link:presentationLink link:definitionLink link:calculationLink 150 - Disclosure - STOCK OPTION PLANS - Cost Related to Unvested Awards Not Yet Recognized and the Weighted Average Periods (Detail) link:presentationLink link:definitionLink link:calculationLink 151 - Disclosure - STOCK OPTION PLANS - Additional Information (Detail) link:presentationLink link:definitionLink link:calculationLink 152 - Disclosure - GRANT INCOME - Additional Information (Detail) link:presentationLink link:definitionLink link:calculationLink 153 - Disclosure - CONTINGENCIES AND COMMITMENTS (Details) link:presentationLink link:definitionLink link:calculationLink 154 - Disclosure - CONTINGENCIES AND COMMITMENTS - Additional Information (Detail) link:presentationLink link:definitionLink link:calculationLink 155 - Disclosure - INCOME TAXES - Summary of Effects of Temporary Differences that Give Rise to Significant Portions of the Deferred Tax Assets (Detail) link:presentationLink link:definitionLink link:calculationLink 156 - Disclosure - INCOME TAXES- Summary of Expected Tax Expense (Benefit) Based on the U.S. Federal Statutory Rate is Reconciled with the Actual Tax Provision (Benefit) (Detail) link:presentationLink link:definitionLink link:calculationLink 157 - Disclosure - INCOME TAXES- Summary of Expected Tax Expense (Benefit) Based on the U.S. Federal Statutory Rate (Detail) link:presentationLink link:definitionLink link:calculationLink 158 - Disclosure - INCOME TAXES - Additional Information (Detail) link:presentationLink link:definitionLink link:calculationLink